Clinical Research

Altered fractionaton - HypoARC

    Standard Fractionation applies 2Gy of radiaton dose, every day for 30-35 fractions. This means that the whole radiotherapy schedule  lasts 6-7 weeks, which is the most common applied schedule worldwide. Why 2Gy and not 4Gy? This was a result of unacceptable  late radiotherapy toxicity, including fibrosis and necrosis of tissues. At least, this was what we believed...but this has now changed. Novel radiotherapy technology allows he administration of higher dose of radiation to the tumor, at the same time keeping low the dose to the surrounding normal organs. Not all tumors are sensitive to 2Gy and, in fact, many tumors, due to hypoxia or intrinsic radioresistance, demand larger daily doses to suffer a good damage. Moreover, by applying large daily doses daily, the total treatment time is reduced to 3-4 weeks, which consists the so called 'accelerated radiotherapy'. In this way, cancer cells cannot proliferate during radiotherapy and, treatment becomes more effective. We, therefore, proposed the concept of Hypofractionatd and Accelerated  Radiotherapy' or HypoAR or, when supported with cytoprotective drugs, HypoARC. During the past 15 years, we obtained a strong experience  by applying such regimens for the treatement of hundreds patients with breast, lung, prostate, bladder and  head-neck cancer, confirming high  efficacy and low  toxicity.

Chemotherapy and Molecular Targeting Radiosensitization