The Tumor And Angiogenesis Research Group

     One of the main sources of funding research conducted in the department of Radiotherapy-Oncology and Radiobiology/Radiopathology is the Tumor and Angiogenesis Research Group.  TARG  is a working group of scientists devoted to basic and/or clinical research into cancer, with special interest in angiogenesis and genes controlling tumour pathogenesis and clinical behaviour. Research into the physiology or pathology of angiogenesis - hypoxia and metabolism  in biological and medical areas other than cancer are also included in the research interests of the working group. TARG has a coordinating role with the aim of maintaining a close relationship between its members, organising member meetings on specific research subjects, proposing and realising research projects and defining the general and project specific duties of the participating members.

     Financial support for the conduct of the research  is also provided through inter-department collaborations within TARG (honorary Chairman: Professor Adrian L Harris, University of Oxford) within projects funded by the Cancer Research UK.

The ARISTEIA project 2012-2015

ΥΠΟΥΡΓΕΙΟ ΠΑΙΔΕΙΑΣ ΚΑΙ ΘΡΗΣΚΕΥΜΑΤΩΝ - ΓΕΝΙΚΗ ΓΡΑΜΜΑΤΕΙΑ ΕΡΕΥΝΑΣ ΚΑΙ ΤΕΧΝΟΛΟΓΙΑΣ  -  ΕΣΠΑ 2007-2013

WP.2 Targeting the Autophago-Lysosomal Kinetics to sensitize cancer cell lines to radiation therapy  Work package leader: Michael I. Koukourakis

W.P.3 Targeting the autophagosome/lysosome pathway to sensitize mice-bearing tumors against radiation therapy. Work package leader: Michael I. Koukourakis, 

WP.4 Regulation of signaling pathways by autophagy/lysosomal biogenesis and heat shock proteins after radiation in normal and cancer cell lines. Work package leader: Nicholaos Grammatikakis

WP5. Clinicopathological study on the Autophagy and Lysosomal markers in the prognosis of cancer patients and response of tumors to chemotherapy and radiotherapy. Work package leader: Alexandra Giatromanolaki

ARISTEIA II PROJECT 2013-2015

ΥΠΟΥΡΓΕΙΟ ΠΑΙΔΕΙΑΣ ΚΑΙ ΘΡΗΣΚΕΥΜΑΤΩΝ -  ΓΕΝΙΚΗ ΓΡΑΜΜΑΤΕΙΑ ΕΡΕΥΝΑΣ ΚΑΙ ΤΕΧΝΟΛΟΓΙΑΣ  -  ΕΣΠΑ 2007-2013    

WP.1 The The pathology of collaboration between cancer cells and stroma in lung cancer. Work package leader: Alexandra Giatromanolaki

WP.2 Comparative evaluation of the co-operative function between cancer and stroma cells, using Next Generation Sequencing technology. Work package leader: Aristotelis Hatziioannou

W.P.3 The metabolic consequences of cancer cell and fibroblast co-cultures in lung cancer. Work package leader: Alexandra Giatromanolaki

WP.4. Growth inhibition and radiosensitizaton of lung cancer cells through metabolic interference. Work package leader: Michael I. Koukourakis

ΑΝΑΠΤΥΞΗ ΜΕΘΟΔΩΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΑΚΤΙΝΕΥΑΙΣΘΗΣΙΑΣ ΤΩΝ ΦΥΣΙΟΛΟΓΙΚΩΝ ΙΣΤΩΝ

 Με το  ερευνητικό έργο αποσκοπούμε στην ανάπτυξης νέων μεθόδων εκτίμησης της ειδικής ευαισθησίας των φυσιολογικών ιστών προς όφελος των ογκολογικών ασθενών που υποβάλλονται σε ακτινοθεραπεία, μέσα από την προσφορά μοριακών εξετάσεων που εξατομικεύουν τη δόση και τα σχήματα ακτινοθεραπείας, αυξάνοντας έτσι τον θεραπευτικό δείκτη.